Water-soluble L-tyrosine derivatives and a process for preparing

Details Water-soluble L-tyrosine derivatives and a process for preparing Water-soluble L-tyrosine derivatives and a process for preparing

1988-10-14

1990-09-11

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562445, 564165, C07C10132

Patent

active

049564897

ABSTRACT:
The invention relates to the preparation of water-soluble L-tyrosine derivatives having the formula ##STR1## where R.sub.1 is a L-malyl, L-lactyl, L-glutamyl or L-aspartyl group, R.sub.2 is a --OH, --OM, methoxy, ethoxy or amino group and M is an alkaline metal, by enzymatic condensation of an acid selected among L-malic, L-lactic, L-glutamic and L-aspartic acids, with a L-tyrosine derivatives selected among the ethyl and methyl esters and the amide of L-tyrosine. The enzyme is obtained from a culture of Micrococcus casealyticus. The compounds where R.sub.1 is a L-malyl or L-lactyl group are new. Said L-tyrosine derivatives are useful in cosmetic and pharmaceutical compositions, such as tanning and sun compositions.

REFERENCES:
Bachmayer et al, Biochim. Biophys. Acta, vol. 302, pp. 399-405 (1973).
Journal of Medicinal Chemistry, vol. 29, No. 6, Jun. 1986, pp. 906-912, The American Chemical Society; Y. Miyashita, French Search Report.

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