Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Patent
1990-03-21
1995-05-02
Robinson, Douglas W.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
536 64, C07K 900
Patent
active
054120721
ABSTRACT:
This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded. The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on. The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof. Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.
REFERENCES:
patent: 4701521 (1987-10-01), Ryser et al.
D. Deprez-De Campeneere, Cancer Chemother. Pharmacol, 2, 25-30 (1979).
Yokoyama et al., 1987, Die Makromoleculare Chemie: Rapid Comm. 8:431-35.
Yokoyama et al., 1989 Die Makromoleculare Chemie Macromolecular Chemistry & Physc. 190:2041-54.
Yokoyama et al., 1990, J. Controlled Release, 11:269-78.
Inoue Shohei
Kataoka Kazunori
Okano Teruo
Sakurai Yasuhisa
Yamada Noriko
Peselev Elli
Research Development Corp. of Japan
Robinson Douglas W.
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