Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Patent
1995-03-08
1997-12-02
Peselev, Elli
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
424 7808, 424 7818, 536 64, 544235, 548422, 562571, C07K 900
Patent
active
056937512
ABSTRACT:
This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded.
The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on.
The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof.
Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.
REFERENCES:
patent: 4609546 (1986-09-01), Hiratani
patent: 4701521 (1987-10-01), Ryser et al.
patent: 4780421 (1988-10-01), Kameda et al.
patent: 4988625 (1991-01-01), Marburg et al.
patent: 5219564 (1993-06-01), Zalipsky
patent: 5412072 (1995-05-01), Sakurai et al.
D. Deprez-De Campeneere et al., Cancer Chemother. Pharmacol. 2:25-30 (1979).
Yokoyama et al., 1987, Die Makromoleculare Chemie: Rapid Comm. 8:431-35.
Yokoyama et al., 1989, Die Makromoleculare Chemie Macromolecular Chemistry & Physc. 190:2041-54.
Yokoyama et al., 1990, J. Controlled Release, 11:269-78.
Inoue Shohei
Kataoka Kazunori
Okano Teruo
Sakurai Yasuhisa
Yamada Noriko
Peselev Elli
Research Development Corporation of Japan
LandOfFree
Water soluble high molecular weight polymerized drug preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Water soluble high molecular weight polymerized drug preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water soluble high molecular weight polymerized drug preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-802400