Water-soluble guanidine derivatives of polyene macrolides and th

Details Water-soluble guanidine derivatives of polyene macrolides and th Water-soluble guanidine derivatives of polyene macrolides and th

1980-12-23

1983-08-02

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 65, A61K 3171, C07H 1708

Patent

active

043966101

ABSTRACT:
New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin, pimaricin, amphotericin B, candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:

REFERENCES:
patent: 3945993 (1976-03-01), Schaffner et al.
patent: 3957754 (1976-05-01), Aszalos et al.
patent: 4195172 (1980-03-01), Falkowski et al.
patent: 4272525 (1981-06-01), Wright

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