Water-soluble glycosylated derivatives of 1,2-dithiin compounds

Details Water-soluble glycosylated derivatives of 1,2-dithiin compounds Water-soluble glycosylated derivatives of 1,2-dithiin compounds

1994-05-26

1995-09-26

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

549 14, 536124, C07D32706, C07D34300, A61K 7035, A61K 31715

Patent

active

054535000

ABSTRACT:
Novel water-soluble mono and disaccharides of 1,2-dithiins, as well as methods for their synthesis and the synthesis of 3,6-bis(hydroxymethyl)-1,2-dithiin, are provided. The water-soluble compounds have useful medicinal applications, e.g., as an antifungal agent or antibacterial agent in a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5202348 (1993-04-01), Towers
Freeman, F. et al. Sulfur Reports 1989, 9, 207-246.
Cimiraglia, R. et al. J. Mol. Str. (Theochem) 1991, 230, 287-293.
Constabel, C. P.; Towers, G. H. N., Planta Medica 1989, 55, 35-37.
Towers, G. H. N.; Champagne, D. B. In Chemistry & Biology of Naturally-Occurring Acetylenes & Related Compounds (NOARC) ed by Lam, J. et al. Elsevier, Amsterdam, 1988, 139-149.
Schroth, W. et al Angew. Chem. Int. Ed. Engl. 1967, 6, 698-699.

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