Water soluble fluorinated fatty acid sulfonate derivatives usefu

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424 189, 424 93, 562 30, 562 1, A61K 4900, G01N 3100, G01N 3348

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active

056608152

ABSTRACT:
The present invention relates to improved imaging agents useful for .sup.19 F magnetic resonance imaging (MRI). More particularly, the present invention relates to fluorinated fatty acid sulfonate derivatives, such as those derived by reaction of fluorinated fatty acids with sulfonated compounds such as taurine analogs or isethionic acid analogs, which offer improved water solubility and biocompatibility.

REFERENCES:
patent: 4612185 (1986-09-01), Dean
patent: 4639364 (1987-01-01), Hoey
patent: 4838274 (1989-06-01), Schweighardt
patent: 4913853 (1990-04-01), Hoey
patent: 4960815 (1990-10-01), Moos
patent: 5070213 (1991-12-01), Huang
patent: 5081304 (1992-01-01), Moos
patent: 5116599 (1992-05-01), Rogers et al.
patent: 5130119 (1992-07-01), Blaszkiewicz et al.
patent: 5210290 (1993-05-01), Gries et al.
patent: 5234680 (1993-08-01), Rogers et al.
patent: 5248498 (1993-09-01), Neumann et al.
patent: 5318770 (1994-06-01), White et al.
patent: 5324504 (1994-06-01), Rogers, Jr. et al.
patent: 5362477 (1994-11-01), Moore et al.
patent: 5385724 (1995-01-01), White et al.
patent: 5397563 (1995-03-01), Rogers
patent: 5401493 (1995-03-01), Lohrmann
McBee et al., "A Grignard Reagent from 3-Chloro-1,1,1-trifluoropropane" J. Am. Chem. Soc. (1948) 70:2910-2911.
Runge, Val M., "Magnetic resonance contrast agents" The Contrast Media Manual, Williams & Wilkins (1992) Chapter 13, pp. 143-160.
Long et al., "An Overview of perfluoroctylbromide --application as a synthetic oxygen carrier and imaging agent for x-ray, ultrasound and nuclear magnetic resonance" Biomat., Art, Cells, Art, Org. (1988) 16(1-3):411-420.
Kimura et al., "Preparation and surface-active properties of sulfopropylated N-alkylperflurooctanamides" J. Am. Oil Chem. Soc. (1984) 61(1):105-107.
Knorr et al., "The influence of the aminosulfonic acid taurine on the efficacy of digoxin and ouabain in the guinea-pig atrium" Arch. de Farmacol. y Toxicol. (1981) 7(3):291-306.
Maxwell, "New techniques in the pharmacokinetic analysis of cancer drugs III nuclear magnetic resonance" Cancer Surveys (1993) 17:415-423.

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