Water-soluble etoposide analogs and methods of use thereof

Details Water-soluble etoposide analogs and methods of use thereof Water-soluble etoposide analogs and methods of use thereof

2007-02-13

2007-02-13

Owens, Amelia A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S359000, C546S133000, C546S187000, C546S197000, C549S298000, C514S305000, C514S254110, C514S321000, C514S316000

Reexamination Certificate

active

10712663

ABSTRACT:
Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-fluoroanilino)-4-desoxy-podophyllotoxin (9) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.

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