Water-soluble esters of camptothecin compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514283, 546 41, 546 48, A61K 31470

Patent

active

056461593

ABSTRACT:
Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.

REFERENCES:
patent: 4031098 (1977-06-01), Sugasawa
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4545880 (1985-10-01), Miyasaka et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
patent: 4894456 (1990-01-01), Wall et al.
patent: 4914205 (1990-04-01), Sawada et al.
patent: 4943579 (1990-07-01), Vishnuvajjala et al.
patent: 4981968 (1991-01-01), Wall et al.
patent: 5004758 (1991-04-01), Boehm et al.
patent: 5049668 (1991-09-01), Wall et al.
patent: 5053512 (1991-10-01), Wani et al.
patent: 5106742 (1992-04-01), Wall et al.
patent: 5122526 (1992-06-01), Wall et al.
patent: 5122606 (1992-06-01), Wani et al.
patent: 5180722 (1993-01-01), Wall et al.
patent: 5225404 (1993-07-01), Giovannella et al.
patent: 5227380 (1993-07-01), Wall et al.
patent: 5244903 (1993-09-01), Wall et al.
patent: 5342947 (1994-08-01), Lackey et al.
patent: 5352789 (1994-10-01), Hinz
patent: 5401747 (1995-03-01), Wall et al.
patent: 5559235 (1996-09-01), Luzzio
Science, vol. 246, Nov. 24, 1989, pp. 1046-1048, Beppino C. Giovanella, et al., "DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts".
Cancer Research, vol. 49, Mar. 15, 1989, pp. 1465-1469, Christine Jaxel, et al., "Structure-Activity Study of the Actions of Camptothecin Derivatives on Mammalian Topoisomerase I: Evidence for a Specific Receptor Site and a Relation to Antitumor Activity".
Cancer Research, vol. 49, Aug. 15, 1989, pp. 4385-4389, Yaw-Huei Hsiang, et al., "DNA Topoisomerase I-Mediated DNA Cleavage and Cytotoxicity of Camptothecin Analogues".
Cancer Treatment Reports, vol. 71, No. 4, Apr. 1987, Hiroshi Nagata, et al., "Action of 7-Ethylcamptothecin on Tumor Cells and Its Disposition in Mice".
Journal of Medicinal Chemistry, vol. 23, 1980, pp. 554-560, Mansukh C. Wani, et al., "Plant Antitumor Agents. 18. Synthesis and Biological Activity of Camptothecin Analogues".
Journal of Medicinal Chemistry, vol. 29, 1986, pp. 1553-1555, Monroe E. Wall, et al., "Plant Antitumor Agents. 22. Isolation of 11-Hydroxycamptothecin from Camptotheca Acuminata Decne: Total Synthesis and Biological Activity ".
Journal of Medicinal Chemistry, vol. 29, 1986, pp. 2358-2363, Mansukh C. Wani, et al., "Plant Antitumor Agents. 23. Synthesis and Antileukemic Activity of Camptothecin Analogues".
Journal of Medicinal Chemistry, vol. 30, No. 10, 1987, pp. 1774-1779, Mansukh C. Wani, et al., "Plant Antitumor Agents. 25. Total Synthesis and Antileukemic Activity of Ring A Substituted Camptothecin Analogues. Structure-Activity Correlations".
Journal of Medicinal Chemistry, vol. 33, No. 3, 1990, pp. 972-978, Allan W. Nicholas, et al., "Plant Antitumor Agents. 29. Synthesis and Biological Activity of Ring D and Ring E Modified Analogues of Camptothecin".
Journal of Biological Chemistry, vol. 260, No. 27, Nov. 25, 1985, pp. 14873-14878, Yaw-Huei Hsiang, et al., "Camptothecin Induces Protein-Liked DNA Breaks Via Mammalian DNA Topoisomerase I".
Journal of Labelled Compounds and Radiopharmaceuticals, vol. XVIII, No. 3, Oct. 5, 1979, pp. 319-329, Peter E. Ronman, et al., "The Preparation of Tritium and Deuterium-Labelled Camptothecin".
Journal of Organic Chemistry, vol. 39, No. 3, 1974, pp. 303-311, Jacob J. Plattner, et al., "Synthesis of Some DE and CDE Ring Analogs of Camptothecin".
Journal of the American Chemical Society, vol. 94, No. 24, Nov. 29, 1972, pp. 8613-8615, Jacob J. Plattner, et al., "Synthesis of Some DE and CDE Ring Analogs of Camptothecin".
Acta Pharmaceutica Sinica, vol. 23, No. 3, 1988, pp. 186-188, L.Z. Lin, et al., "A New Alkaloid--18-Hydroxycamptothecin" (with English Abstract).
Pan et al. Chemical Abstracts, vol. 84, 1976, p. 13, AN 84-115629p.
Yang et al Chemical Abstracts, vol. 100, 1984, p. 683, AN 100-139434w.
Database WPI, Derwent Publications, AN 89-179979/25, Dec. 1, 1987, EP 321 122, Jun. 21, 1989.
Molecular and Cellular Biology, vol. 7, No. 1, Jan. 1987, pp. 141-148, David S. Gilmour, et al., "Localization of Specific Topoisomerase I Interactions Within the Transcribed Region of Active Heat Shock Genes by Using the Inhibitor Camptothecin".
Journal of Organic Chemistry, vol. 39, No. 23, 1974, pp. 3430-3432, S. Danishefsky, et al., "Synthesis and Biological Evaluation of DE-AB-Camptothecin".
Chemical Abstracts, vol. 84, p. 786, Compound 115631h.
Yakult Chemical Abstracts, vol. 97, 1982, AN 97-188278b.
Yakult Chemical Abstracts, vol. 101, 1984, AN 101-91322z.
Yakult Chemical Abstracts, vol. 101, 1984, AN 101-130677r.
Database WPI, Derwent Publications, AN 84-104015/17, JP-A-59 046 284, Mar. 15, 1984.
Database WPI, Derwent Publications, AN 84-110812/18, JP-A-59 051 288, Mar. 24, 1984.
Proceedings of the Annual Meeting of the American Society of Clinical Oncology, 1989, AN 8:A1019, R. Ohno, et al., "A Clinical Study of a Camptothecin Derivative, CPT-11, on Hematological Malignacies" (Abstract).
Proceedings of the Annual Meeting of the American Association for Cancer Research, 1989, AN 30:A2476, Y.H. Hsiang, et al., "Structure-Activity Studies of 20(S)-Camptothecin Analogs" (Abstract).
Proceedings of the Annual Meeting of the American Association for Cancer Research, 1989, AN 30:A2485, R.P. Hertzberg, et al., "Irreversible Trapping of the DNA-Topoisomerase I Covalent Complex and Affinity Labeling of the Camptothecin Binding Site with 10-Bromoacetamidomethylcamptothecin" (Abstract).
Proceedings of the Annual Meeting of the American Association for Cancer Research, 1988, AN 29:A1080, Y. Pommier, et al., "Structure-Activity Study of the Relation Between Topoisomerase I Inhibition and Antitumor Activity of Camptothecin" (Abstract).
T.R. Govindachari, et al., "9-Methoxycamptothecin: A New Alkaloid from Mappia Foetida Miers," pp. 453-454.
Chemical Abstracts, vol. 103, No. 9, AN 64374c (1987).
Chemical Abstracts, vol. 101, No. 10, AN 78770z (Citation) (1984).
Chemical Abstracts, vol. 100, No. 21, AN 167724j (1983).
Chemical Abstracts, vol. 96, No. 9, AN 69271p (1981).
Chemical Abstracts, vol. 95, No. 15, AN 133209h (1981).
Chemical Abstracts, vol. 94, No. 12, AN 90169e (1980).
Chemical Abstracts, vol. 94, No. 1, AN 4143n (1980).
Chemical Abstracts, vol. 92, No. 5, AN 37766e (1977.
Chemical Abstracts, vol. 92, No. 3, AN 18799b (1979).
Chemical Abstracts, vol. 90, No. 3, AN 22857v (1978).
Journal of Medicinal Chemistry, vol. 36, No. 18, pp. 2689-2700, 1993, M. WAll, et al., "Plant Antitumor Agents. 30.sup.1a,b Synthesis and Structure Activity of Novel Camptothecin Analogs".
Database WPI, Derwent Publications, AN 95-161578/21, WO 95-10304, Apr. 20, 1995.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Water-soluble esters of camptothecin compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Water-soluble esters of camptothecin compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water-soluble esters of camptothecin compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2409064

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.