Water-soluble dry solid containing proteinaceous bioactive subst

Details Water-soluble dry solid containing proteinaceous bioactive subst Water-soluble dry solid containing proteinaceous bioactive subst

1987-08-31

1989-04-25

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 530399, 424 851, 424 941, 424 942, 424 943, 514 2, 514 3, 514 8, 514 23, 435102, 435188, 536 11, C07K 1500, A61K 3702, A61K 3724, A61K 3748

Patent

active

048249386

ABSTRACT:
Proteinaceous bioactive substances (including lymphokine and peptide hormone) in dry solid are extremely stabilized by the presence of the specific polysaccharide mainly composed of repeating maltotriose units. Pullulan, elsinan, and their partial hydrolysates are feasible as the polysaccharide. The weight ratio of the polysaccharide to the substance which effectively stabilizes the latter substance is at least 0.5 on the basis of dry solids. The dry solid is advantageously usable as a test reagent, injection, granule, tablet, suppository or ointment.

REFERENCES:
patent: 4247642 (1981-01-01), Hirohara et al.
patent: 4372883 (1983-02-01), Matuhashi et al.
patent: 4474756 (1984-10-01), Mitsuhashi et al.
patent: 4536387 (1985-08-01), Sakamoto et al.
Mitsuhashi et al., CA, vol. 97, 1982, #188261r.
Matsuhashi et al., CA, vol. 95, 1981, #17578y.

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