Water-soluble drugs and methods for their production

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C540S461000

Reexamination Certificate

active

07026350

ABSTRACT:
The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of producing water-soluble analogues of water-insoluble drugs through derivatization and conjugation with a polar moiety via a thiol ether bond with a heterobifunctional linking molecule.

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patent: WO 94/06750 (1994-03-01), None
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Schnur et al. (Journal of Medicinal Chemistry (1995), 38, 3806-3812).
Hawthorne et al., “Liposomes as Drug Delivery Vehicles for Boron Agents,”J. Neurooncol., 33(1-2), 53-58 (May 1997).
Schacter et al., “Clinical and Pharmacokinetic Overview of Parenteral Etoposide Phosphate,”Cancer Chemother. Pharmacol., 34 Suppl., S58-63 (1994).
Sweetana et al., “Solubility Principles and Practices for Parenteral Drug Dosage Form Development,”PDA J. Pharm. Sci.&Tech., 50, 330 (1995).

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