Water soluble drug complex and method for production of same

Details Water soluble drug complex and method for production of same Water soluble drug complex and method for production of same

1985-03-27

1987-08-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 37, 514 78, 514220, 514573, A61K 3170, A61K 31685, A61K 31545

Patent

active

046877622

ABSTRACT:
The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent, (2) removing the solvent to leave behind a drug-containing phospholipid film, (3) suspending the resulting film in an aqueous solution, (4) ultrasonicating the film, (5) centrifuging the resulting suspension, and (6) recovering the lowermost layer of the resulting sediment to yield the water-soluble complex. The above complex can be administered parenterally as well as by the oral and other routes, and is so rich in the drug component that a remarkably increased drug activity can be realized.

REFERENCES:
patent: 4196202 (1980-04-01), Okoida
patent: 4239754 (1980-12-01), Sache et al.
patent: 4328222 (1982-05-01), Schmidt
patent: 4372949 (1983-02-01), Kodama et al.
patent: 4377567 (1983-03-01), Geho
patent: 4411894 (1983-10-01), Schrank et al.
patent: 4880041 (1984-10-01), Myles et al.
Gibbes et al., Biochemistry, vol. 16, No. 12, (1977), pp. 2806-2810.

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