Water soluble derivatives of taxol

Details Water soluble derivatives of taxol Water soluble derivatives of taxol

1991-05-01

1994-10-04

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

053528050

ABSTRACT:
Sulfonated 2'-acryloyltaxol and sulfonated 2'-O-acyl acid taxol derivatives are synthesized which have improved water solubility and stability while maintaining bio-activity. In particular, 2'-[(3-sulfo-1-oxopropyl)oxy]taxol sodium salt is synthesized by reacting taxol with acrylic acid, and subsequently reacting the 2'-acryloyltaxol with bisulfite in a Michael reaction. 2'-{[4-((2-sulfoethyl)amino)-l,4-dioxobutyl]oxy} taxol sodium salt and 2'-{[4-((3-sulfopropyl)amino)-1,4-dioxobutyl]oxy} taxol sodium salt are synthesized by reacting 2'-succinyltaxol with the tetrabutylammonium salts of taurine and 3-aminopropyl sulfonic acid, respectively, and subsequently exchanging the ammonium with sodium. Glycol derivatives of 2'-O-acyl acid taxols with improved water solubility are synthesized by reaction of a glycol with 2'-O-acyl acid taxol.

REFERENCES:
patent: 4942184 (1990-07-01), Haugwitz et al.

Affiliated with

Also associated with

Rating

Water soluble derivatives of taxol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Water soluble derivatives of taxol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water soluble derivatives of taxol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582590