Water-soluble derivatives of paclitaxel, method for producing sa

Details Water-soluble derivatives of paclitaxel, method for producing sa Water-soluble derivatives of paclitaxel, method for producing sa

1998-07-01

1999-11-09

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514480, 5483391, 549510, 562562, 562563, 562570, 562573, A61K 3127, A61K 34415, C07D23364, C07D30514

Patent

active

059815647

ABSTRACT:
The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid derivatives of the glutarylpaclitaxel, all of which possess the cytotoxicity activity of the parent compound, paclitaxel. Also disclosed are fluorescent derivatives of paclitaxel for determining a concentration of paclitaxel in a medium or for detecting apoptotic cancer cells.

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