Water-soluble derivatives of lipophilic drugs

Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,...

Reexamination Certificate

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C436S161000, C436S530000, C436S815000, C540S507000, C540S510000

Reexamination Certificate

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07029918

ABSTRACT:
A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I):in-line-formulae description="In-line Formulae" end="lead"?G-(L)n—Y;  (I)in-line-formulae description="In-line Formulae" end="tail"?where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as —SO3−, —NR—SO3−, —P(═O)(OH)(O−), or —O—P(═O)(OH)(O−); where R is H or an alkyl group of 1 to 10 carbon atoms.

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