Water soluble derivatives of fredericamycin A

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 15, A61K 31435, C07D22118, A01N 4342

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active

046736786

ABSTRACT:
Water soluble, biologically active derivatives of Fredericamycin A (FMA) and method of synthesizing the same are described. Antibiotic pharmaceutical compositions of the new water soluble compounds of FMA are useful antimicrobial and antitumor preparations.

REFERENCES:
patent: 4584377 (1986-04-01), Yokoi et al.
Pandey et al., (1981) J Antibiotics, vol. 34, No. 11, pp. 1389-1401 "Fredericamycin A, A New Antitumor Antibiotic I."
Warnick-Pickle et al. (1981) J. Antibiotics, vol. 34, No. 11, pp. 1402-1407 "Fredericamycin A, A New Antitumor Antibiotic II."
Hilton et al., (1986) Biochemistry, 25:5533 "Magnetic Resonance Studies of Fredericamycin A".
Byrne et al., (1985) Biochemistry 24:478 "Biosynthesis of Fredericamycin A".
Misra et al., (1982) J. American Chemical Society, 104:4478 "Fredericamycin A, An Antitumor Antibiotic of a Novel Skeletal Type".

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