Water soluble derivatives of cephalex and process for their prep

Details Water soluble derivatives of cephalex and process for their prep Water soluble derivatives of cephalex and process for their prep

1982-12-22

1984-09-11

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50104, C07D50122

Patent

active

044711158

ABSTRACT:
The water soluble derivatives of cephalexin, having general formula: ##STR1## wherein X represents an alkali metal or the organic nitrogen containing cation of a basic aminoacid, combine the typical antibiotic action of cephalexin with the water solubility and form essentially neutral, aqueous solutions. The process for the preparation of the above derivatives comprises a first step in which the methylol derivative of cephalexin is prepared and a second step in which the treatment with a suitable base is carried out.

REFERENCES:
patent: 3634417 (1972-01-01), Attenburrow
patent: 3741963 (1973-06-01), Dursch et al.
patent: 3796709 (1974-03-01), Breuer et al.
patent: 3880842 (1975-04-01), Lee
patent: 3988326 (1976-10-01), Seki et al.

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