Water soluble derivatives of cannabinoids

Details Water soluble derivatives of cannabinoids Water soluble derivatives of cannabinoids

1998-05-29

1998-12-08

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

5142328, A61K 31533, C07D41312

Patent

active

058471286

ABSTRACT:
Water-soluble esters of tetrahydrocannabinoids, which are well-suited for administration in therapeutic aqueous formulations, having following general formula: ##STR1## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a substituent such as a lower alkyl group, and the pharmaceutically acceptable salts of these compounds.

REFERENCES:
patent: 4179517 (1979-12-01), Mechoulam et al.
patent: 4327028 (1982-04-01), Kaplan
patent: 4876276 (1989-10-01), Mechoulam et al.
patent: 5338753 (1994-08-01), Burstein et al.
patent: 5389375 (1995-02-01), ElShohly
Struwe, Annals of Pharm., 27, pp. 827-831, (1993).
AIDS Res. Hum. Retroviruses, 13(4), p. 305, 1997.
"Water-Soluble Derivatives of .increment..sup.1 -Tetrahydrocannabinol", Science, vol. 177, Aug. 1972.
Razdan et al., "Drugs Derived from Cannabinoids. 2 .sup.1a Basic Esters of Nitrogen and Carbocyclic Analogs", Journal of Medicinal Chemistry, vol. 19, No. 4, 1976.

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