Water-soluble derivative of 6-deoxy-tetracyclines

Details Water-soluble derivative of 6-deoxy-tetracyclines Water-soluble derivative of 6-deoxy-tetracyclines

1975-09-25

1977-11-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260559HT, 260351, A61K 3165

Patent

active

040606058

ABSTRACT:
This invention relates to a novel water soluble derivatives of 6-deoxy-tetracyclines, particularly of doxycycline, in which a methionine group is linked to the tetracycline group through a methylene bridge, thus obtaining a derivative which is not only water soluble at neutral pH, but also endowed with outstanding properties from the point of view of the therapeutical use.

REFERENCES:
patent: 3275652 (1966-09-01), Martell, Jr. et al.
patent: 3388161 (1968-06-01), Pavia et al.
patent: 3461161 (1969-08-01), Rogalski et al.
patent: 3483199 (1969-12-01), Silva
patent: 3637741 (1972-01-01), Mayama et al.
patent: 3637826 (1972-01-01), Intelisano
patent: 3835190 (1974-09-01), Lazarera et al.
patent: 3847973 (1974-11-01), Vinals et al.

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