Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1992-07-23
1994-09-06
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 424 854, 514 2, 514 12, 514 21, A61K 4505
Patent
active
053446445
ABSTRACT:
A water soluble composition is described which comprises (a) a water soluble pharmacologically active peptide selected from the group consisting of cytokines or haematopoietic factors and (b) a sulfate group-containing acidic mucopolysaccharide and/or a desulfated modification of a naturally occurring sulfate group containing acidic mucopolysaccharide, and which brings about prolonged action of pharmacologically active peptides in a living body.
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Ramsden, et al., "Selective & differential binding . . . " Eur. J. Immunol., vol. 22, pp. 3027-3031, 1992.
D. M. Sylvester et al., "Augmentation of Antimetastatic Activity of Interferon and Tumor Necrosis Factor by Heparin"; Immunopharmacology and Immunotoxicology 12(2), 161-180 (1990).
D. E. Ingber et al., "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steriods: Induction of Capillary Basement Membrane Dissolution" Endo. 1986, vol. 119, No. 4, pp. 1768-1775.
D. Gospodarowicz et al.; "Heparin Protects Basis and Acidic FGF from Inactivation", Journal of Cellular Physiology 128:475-484 (1986).
Igari Yasutaka
Ishiguro Seiko
Yamada Minoru
Conlin David G.
Neuner George W.
Sayala C.
Takeda Chemical Industries Ltd.
Wityshyn Michael G.
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