Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-02-29
1990-04-24
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514471, 514635, 514646, 548500, 548543, A61K 31405, A61K 3141, C07D20928, C07D207267
Patent
active
049201450
ABSTRACT:
A method for increasing the water-solubility of highly insoluble organic compounds by forming a novel complex product from the reaction between the organic compound and an oligomer of vinylpyrrolidone. The complex is highly stable and results in solubilities of the organic compounds in excess of 25-fold.
REFERENCES:
patent: 4663348 (1985-07-01), Chafetz
patent: 4831194 (1989-05-01), Kreidl et al.
Colwell et al., J. of Med. Chem., 17, pp. 142-144, (1974).
Cho James R.
Cottrell Ian W.
Smith Terry E.
GAF Chemical Corporation
Goldberg Jules E.
Maue Marilyn J.
Springer David B.
Ward Joshua J.
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