Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-31
1997-09-23
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 5142285, 514279, 544 60, 544125, 544361, 546 41, A61K 3147, C07D491147
Patent
active
056705000
ABSTRACT:
The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
REFERENCES:
patent: 4939255 (1990-07-01), Tagawa
patent: 5004758 (1991-04-01), Boehm et al.
Wall, et al., "Plant Antitumor Agents. 30..sup.1a,b Synthesis and Structure Activity of Novel Captothecin Analogs", (1993), J. Med. Chem., 36:2689-2700.
Masuda et al., "CPT-11: A New Derivative of Camptothecin for the Treatment of Refractory or Relapsed Small-Cell Lung Cancer", (1992), J. Clin. Oncology, 10:1225-1229.
Berges David A.
Taggart John J.
Daus Donald G.
Lentz Edward T.
SmithKline Beecham Corporation
Stercho Yuriy P.
Venetianer Stephen A.
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