Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-28
2000-04-04
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 41, C07D491147, A61K 31435
Patent
active
060462094
ABSTRACT:
The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
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Wall, et al., "Plant Antitumor Agents. 30..sup.la,b Synthesis and Structure Activity of Novel Captothecin Analogs", (1993), J. Med. Chem., 36:2689-2700.
Masuda, et al., "CPT-11: A New Derivative of Camptothecin for the Treatment of Refractory or Relasped Small-Cell Lung Cancer", (1992), J. Clin. Oncology, 10:1225-1229.
Berges David A.
Taggart John J.
Kifle Bruck
Kinzig Charles M.
Shah Mukund J.
SmithKline Beecham Corporation
Stercho Yuriy P.
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