Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-31
1997-09-02
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 41, A61K 3147
Patent
active
056631774
ABSTRACT:
The present invention provides a water soluble camptothecin analog of Formula I: ##STR1## which is particularly useful as an antineoplastic agent; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
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patent: 5004758 (1991-04-01), Boehm et al.
patent: 5061795 (1991-10-01), Tagawa et al.
Masuda, et al., "CPT-11: A New Derivative of Camptothecin for the Treatment of Refractory or Relapsed Small-Cell Lung Cancer", (1992), J. Clin. Oncology, 10:1225-1229.
Wall, et al., "Plant Antitumor Agents. 30..sup.la,b Synthesis and Structure Activity of Novel Captothecin Analogs", (1993), J. Med. Chem., 36:2689-2700.
Berges David A.
Taggart John J.
Daus Donald G.
Lentz Edward T.
SmithKline Beecham Corporation
Stercho Yuriy P.
Venetianer Stephen A.
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