Water soluble azo dyes and their synthesis and use

Details Water soluble azo dyes and their synthesis and use Water soluble azo dyes and their synthesis and use

1999-11-09

2000-04-04

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

436 95, C09B 29036, C09B 2909, G01N 3352

Patent

active

060463120

ABSTRACT:
Disclosed are water soluble azo dyes, represented by Formula I or II, and their synthesis and use. The water soluble azo dyes are synthesized by diazotizing 4-aminopyridine and coupling the resulting diazo intermediate with alkylated metanilic or orthanilic acid. To be suitable for measuring blood glucose levels, the dyes are combined with m-nitrophenyl boronic acid in an aqueous solvent. A combined ao form of the dyes with glucose shows a peak at 540 nm. At this wavelength, the absorptivity has a tendency to increase with the increasing of glucose level, which allows the measurement of blood glucose levels. ##STR1## wherein R has a 1-4 carbon atom length and is an alkyl, a hydroxy alkyl, a carboxyl-containing alkyl, or a sulfonyl-containing alkyl.

REFERENCES:
patent: 5298608 (1994-03-01), Murayama et al.
Koumoto et al., Chemical Abstracts, 130:89807, 1998, "Design of a Visualized Sugar Sensing System Utilizing a Boronic Acid-Azopyridine Interaction".

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