Water soluble, antineoplastic derivatives of taxol

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549510, 549511, 5142278, 5142328, 514255, 514422, 544 587, 544147, 544375, 546196, 548525, A61K 31335, C07D30514

Patent

active

049421840

ABSTRACT:
Antineoplastic, water soluble, taxol derivatives and methods for preparing the same are described.

REFERENCES:
Manfredi and Horwitz, 1984, Pharmac. Ther., 25:83-125.
Magri et al., Journal of Natural Products, 51:298-306, 1988.
Magri et al., J. Org. Chem., 51:797-802, 1985.
Lataste et al., Proc. Natl. Acad. Sci. U.S.A., 81:4090-4094, 1984.
Mellado et al., Biochemical and Physical Research Communications, 124:329-336, 1984.
Parness et al., Biochemical and Biophysical Research Communiations, 105:1082-1089, 1982.
Deutsch et al., 1989, J. Med. Chem., 32:788-792.

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