Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-08-25
1995-11-14
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514217, 540542, 540589, A61K 3155, A61K 31675, C07D22328, C07F 9553
Patent
active
054666830
ABSTRACT:
The present invention relates to novel water-soluble analogs of carbamazepine and compositions containing them. The novel compositions are particularly suited for intravenous administration. The analogs of carbamazepine are useful in the treatment of epilepsy and related disorders.
REFERENCES:
patent: 3185679 (1965-05-01), Schindler et al.
patent: 3637661 (1972-01-01), Schindler
L. Gram et al., "Carbamazepine Toxicity," Antiepileptic Drugs, Third Edition, Ed. R. Levy et al., New York: Raven Press, Ltd. (1989), pp. 555-565.
M. Dam et al., "Potential Antiepileptic Drugs: Oxcarbazepine," Antiepileptic Drugs, Third Edition, Ed. R. Levy et al., New York: Raven Press, Ltd. (1989), pp. 913-924.
R. Heckendorn, "Synthesis of trans-10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide, a Major Metabolite of Carbamazepine," Helvetica Chimica Acta, vol. 70 (1987), pp. 1955-1962.
E. A. Swinyard et al., "General Principles: Experimental Selection, Quantification, and Evaluation of Anticonvulsants," Antiepileptic Drugs, Third Edition, Ed. R. Levy et al., New York: Raven Press, Ltd. (1989), pp. 85-102.
S. A. Varia et al., "Phenytoin Prodrugs III: Water-Soluble Prodrugs for Oral and/or Parenteral Use," Journal of Pharmaceutical Sciences, vol. 73, No. 8, Aug. 1984, pp. 1058-1059; 1070-1073.
R. D. Smith et al., "Pharmacology of ACC-9653 (Phenytoin Prodrug)," Epilepsia, vol. 30, Suppl. 2, (1989), pp. S15-S21.
Herzig Yaacov
Sterling Jeff
Datlow Philip I.
Teva Pharmaceutical Industries Ltd.
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