Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1977-07-15
1980-09-02
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Lymphokine
2601125R, 424177, A61K 3900, C07C10352, A61K 3700
Patent
active
042206375
ABSTRACT:
The invention relates more particularly to the diamide of the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutam ic acid, to the pharmaceutical compositions containing said compound in association with a pharmaceutical vehicle. Of particular interest are the oil-free compositions containing said compound, particularly the oil-free aqueous sterile isotonic injectable solutions. These compositions are useful as adjuvants for enhancing the immune response to vaccinant antigens, particularly weak immunogens.
REFERENCES:
patent: 4082735 (1978-04-01), Jones et al.
patent: 4082736 (1978-04-01), Jones et al.
F. Ellouz, et al., Biochem. and Biophys. Res. Comm., 59, 1974, pp. 1317-1325.
Ghuysen, et al., Bact. Membranes and Walls, 1973, pp. 39-41.
Chaturvedi, J. Med. Chem., 9, 1966, pp. 971-973.
Kotani, et al., Sympos. Internat. on Bact. Immun. Stimulants, 1973, p. 8.
Lamzelotti, et al., J. Am. Chem. Soc., 86, 1964.
Kotani, et al., Biken J., 13, 105-111, 1975.
Adam, et al., Biochem. and Biophys. Res. Commun., 72, 1976, pp. 339-346.
Chem. Abst., 87, 1977, pp. 199018m, 118075c, 51519e.
Audibert Francoise
Chedid Louis
Choay Jean
Lederer Edgar
Lefrancier Pierre
Agence Nationale de Valorisation de la Recherche
Phillips Delbert R.
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