Water soluble adenosine kinase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 271, 536 272, 536 2721, 536 2723, 536 276, 536 2762, 536 2763, 536 277, C07H 1916

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057959773

ABSTRACT:
This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to water soluble, aryl substituted 4-amino analogs having activity as adenosine kinase inhibitors The invention also relates to the preparation and use of these adenosine kinase inhibitors in the treatment of cardiovascular, and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.

REFERENCES:
patent: 4455420 (1984-06-01), Kazlaukas
patent: 4904666 (1990-02-01), Friebe et al.
Abdalla, G.M. and Sowell, J.W., Sr., J. Heterocyclic Chem. 24, 297-301 (1987).
Achtenberg et al., Biochem. J., 235, 13-17 (1986).
Agarwal, K.C., et al, Biochem. Pharmacol., 28, 501-10 (1978).
Amarnath, V. and Madhav, R., Synth. 837, 846-51 (Dec. 1974).
Bergstrom, D.E., et al., J. Med. Chem., 27, 285-92 (1984).
Bontemps et al., Proc. Natl. Acad. Sci. USA, 80, 2829-33 (1983).
Caldwell and Henderson, Cancer Chemother. Rep., 2, 237-46 (1971).
Carboni, R.A., et al., J. Am. Chem. Soc., 80, 2838-40 (1958).
Chat, I., et al., J. Med. Chem., 18, 161-65 (1975).
Cottam, H.B., et al., J. Med. Chem., 27, 119-27 (1984).
Davies et al., Biochem. Pharmacol., 35, 3021-29 (1986).
Davies et al., Biochem. Pharmacol., 33, 347-55 (1984).
Davoll, J., J. Chem. Soc., 131-38 (1960).
Divekar, A.Y. and Hakala, M.T., Mol. Pharmacol., 7, 663-73 (1971).
Firestein et al., J. Immunology 154, 326-34 (1995).
Gerwald, R., Z. Chem., 1, 349 (1961).
Green, J. Supramol. Structure, 13:175-182 (1980).
Henderson et al., Cancer Chemotherapy Rep. Part 2, 3, 71-85 (1972).
Hinshaw, B.C., et al., J. Heterocyclic Chem., 6, 215-21 (1969).
Ikehara, M., et al., Tetrahedron, 26, 5757-63 (1970).
Keil et al., Life Sciences 5, 171-76 (1992).
Kobayashi, S., Chem. Pharm. Bull., 21, 941-51 (1973).
Newby et al., Biochem. J., 214, 317-323 (1983).
Noell, C.W., et al., J. Heterocyclic Chem., 1, 34-41 (1964).
Miller et al., J. Biol. Chem., 254, 2346-52 (1979).
Pak et al., Soc. for Neuroscience Abs., 20, 149.2 (1994).
Phillis et al., Life Sciences, 53, 497-502 (1993).
Prescott et al., Nucleosides & Nucleotide, 8, 297 (1989).
Pudlo, J.S., et al., J. Med. Chem., 33, 1984-92 (1990).
Rosemeyer, H. and Seela, F., Helv. Chim. Acta, 71, 1573-85 (1988).
Schrader, in Regulatory Function of Adenosine; Berne et al., eds. pp. 133-156 (1983).
Sciotti et al., J. Cerebral Blood Flow Metab., 13, 201-207 (1993).
Seela, F., et al., Liebigs Ann. Chem., 15-19 (1987).
Stout, M.G., et al., J. Org. Chem., 33, 1219-25 (1968).
Synder, J.R. et al., Carbohydrate Res., 163, 169-88 (1987).
Taylor, E.C. and Hendess, R.W., J. Am. Chem. Soc. 87, 1995-2003 (1965).
Taylor, E.C., et al., J. Org. Chem., 31, 342-43 (1966).
Tominaga, Y., et al., J. Heterocyclic Chem., 27, 647-60 (1990).
White, Soc. Neurosci. Abs., 20, 308.9 (1994).
Wu, et al., Cytobios, 50, 7-12 (1987).
Zhang et al., J. Pharmacol. Exper. Ther. 264(3), 1415 (1993).
Zoref-Shani et al., J. Mol. Cell. Cardiol., 20, 23-33 (1988).

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