Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Reexamination Certificate
1993-12-23
2001-07-31
Levy, Neil S (Department: 1616)
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
C424S405000, C424S407000, C424SDIG001, C514S718000
Reexamination Certificate
active
06267947
ABSTRACT:
BACKGROUND AND SUMMARY OF THE INVENTION
This invention relates to novel pesticide compositions and methods for their use in topical veterinary topical applications. More particularly, this invention is directed to water/perspiration resistant pesticide compositions comprising a solution of a water swellable polycarboxylated polymer and a pesticide in a substantially nonaqueous liquid carrier.
There are many species of biting insects, including mosquitoes, ticks, mites, and horse flies, which prey upon vertebrate species. These insect species not only inflict discomfort by their bites, but they also can transmit disease. The sharp pain associated with insect bites can indirectly result in other injury when, for example, the animal reacts with sudden unexpected reflexive movements. Since the timing of an insect's bite is unpredictable, a docile animal may react in a sudden violent manner. This is especially a problem for equestrians. Horses are frequently bitten by horseflies causing them to bolt unexpectedly, throwing their rider. For these reasons it is desirable to protect vertebrate species, and in particular domesticated animals, from being bitten by insects.
One means of protecting animals from biting insects is to treat the animal with an insecticide or insect repellent. Pesticides suitable for such uses are well known to those familiar with the art, and as used herein the term “pesticide” embraces insecticides, herbicides, fungicides, nematocides, miticides, bactericides, pest repellents, and combinations thereof. Typically, pesticide formulations for veterinary use are applied as a spray, lotion, cream or powder to the animal. Although currently available pesticidal formulations are effective to prevent insects from biting animals, their efficacy is diminished due to their water solubility; as the pesticide treated animal surface (typically hair or skin) comes into contact with water, the pesticide is washed from the treated surface. Topically applied pesticide formulations are often prematurely washed from the treated surface by rain, or as an animal becomes active, the animal's own perspiration. Removal of the applied pesticide renders the animal susceptible to insect attack.
It would thus be desirable to provide a topical pesticide composition for veterinary use that is easy to apply and capable of sustained retention on the treated surface in the presence of water. It is also desirable that such composition be readily washable from the surface when pesticidal functionality is no longer necessary.
The present invention provides a pesticide composition suitable for topical application to an animal or other surface exposed to humid or wet conditions. The composition comprises a solution of a water swellable hydrophilic polymer and a pesticide in a substantially nonaqueous liquid medium. Advantageously, the hydrophilic polymer functions to entrap the pesticide within the polymer matrix and also exhibits good affinity to the surface. The surface applied pesticide formulation is resistant to being washed from the surface by the perspiration of the animal and thus provides prolonged protection from insect bites even while the animal is active. Indeed, ambient humidity and moisture from other sources co-act with the applied pesticide/polymer matrix to swell the matrix and facilitate pesticide release from the matrix.
The present pesticide composition is formulated for rapid evaporation at ambient temperatures. When applied to animal coats, it evaporates to provide a surface adherent layer of the pesticide entrapping polymer matrix. As the animal becomes active, the polymer matrix becomes hydrated, both from animal perspiration and/or from ambient moisture, swells and thereby allows the pesticide to diffuse from the matrix. Thus, the polymer matrix formed during drying of the present composition functions to provide sustained insect protection to the animal not only by increasing the adherence of the pesticide formulation to the animal (more specifically to its skin or surface hair), but also by functioning to gradually release effective quantities of pesticide formulation.
In another embodiment of this invention there is provided the method of prolonging the pesticidal efficacy of a topical pesticide formulation comprising the pesticide in a substantially non-aqueous liquid carrier. The method comprises the step of dissolving about 0.25% to about 10% by volume of a water swellable polycarboxylated polymer in said pesticide formulation. The formulation can be applied topically and after allowing time for the liquid carrier to evaporate, provide prolonged topical pesticidal activity to prevent or reduce insect bites.
Additional objects, features, and advantages of the invention will become apparent to those skilled in the art upon consideration of the following detailed description of preferred embodiments exemplifying the best mode of carrying out the invention as presently perceived.
DETAILED DESCRIPTION OF THE INVENTION
In accordance with this invention there is provided a topical, perspiration/water resistant pesticide composition, particularly adapted for topical veterinary applications. Pesticide formulations, including particularly insect repellents and insecticides are well known in the art. Known pesticides suitable for use in the present composition are disclosed in U.S. Pat. No.3,576,760 issued Apr. 27, 1971 and U.S. Pat. No. 3,060,084, issued Oct. 23, 1962, specifically incorporated herein by reference. The most widely used insect repellant is N,N-diethyl-m-toluamide, however, other compounds recognized for their insect repellant properties include Ethohexadiol, dimethyl phthalate, dimethyl ethyl hexanediol carbate and butopyronoxyl [butyldimethyl dihydro-gamma-pyrone carboxylate].
In one preferred embodiment of this invention, the pesticide formulation comprises a nonaqueous solution of a water swellable polycarboxylated polymer and permethrin and pyrethrins. Pyrethrins are the active insecticidal constituents of pyrethrum flowers (Chrysanthemums). Although Pyrethrins are an effective insecticide, their use is limited because they will oxidize and become inactive in air. Permethrin [3-(phenoxyphenyl) methyl (±)-cis,trans-3(2,2-dichloroethenyl)-2,2-dimethyl cyclopropanecarboxylate] is a more stable compound that provides long lasting pesticidal activity. These two pesticides are often combined with piperonyl butoxide, which blocks detoxification of the pyrethrins by the insect, and/or an insect repellant such as N-octyl bicycloheptene dicarboximide.
When formulated as a nonaqueous or substantially nonaqueous solution/suspension, pesticides can be combined with a water swellable polycarboxylated polymer to provide a water-resistant formulation in accordance with this invention particularly adapted for topical veterinary use. Such a formulation represents an improvement over prior art pesticide formulations in that the polymer-pesticide combination provides sustained protection from insect bites to a perspiring animal. The pesticidal efficacy of the pesticide formulation is prolonged due to the enhanced retention of the polymer (and the entrapped pesticide ingredients) on the animal's hair and skin, and as well the prolonged water-mediated release of the pesticide(s) from the applied polymer matrix. Advantageously, the present composition remain bound to an animal's hair and skin upon exposure to water, but can be removed by a detergent solution.
Hydrophilic polymers suitable for use in accordance with this invention are water swellable polymers that are soluble in the substantially nonaqueous solvent used as the fluid carrier for the formulation — at least soluble to the extent necessary for dissolution of functional amounts of the polymer in the present compositions. Preferred polymers for use in this invention are water swellable polycarboxylated polymers, including homopolymers or copolymers of acrylic acid or methacrylic acid.
One preferred group of polymers exhibiting the described functionality in accordance wit
Barnes & Thornburg
Levy Neil S
Sun Glitz Corporation
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