Compositions – Solids with solution or dispersion aids
Patent
1998-04-24
2000-03-14
Lovering, Richard D.
Compositions
Solids with solution or dispersion aids
424501, 426 98, 510446, 514952, 516 99, 516108, A61K 916, C09K 300, C11D 337
Patent
active
06036887&
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to water-redispersible granules comprising an active ingredient in liquid form, a process for the preparation thereof and the use thereof.
In some industries, such as the food, cosmetics or paint industries, formulations are prepared from active ingredients in the form of a hydrophobic liquid. One formulation possibility is to prepare oil-in-water emulsions of such ingredients.
However, such emulsions cause stability problems on storage. The phases of the emulsion constituents are seen to separate to a greater or lesser extent. Further, there may be problems with deactivation of the active ingredient to contend with, the active ingredient possibly degrading by hydrolysis during storage.
Finally, the fact that in order to be readily manipulatable and pumpable, such formulations must contain relatively low quantities of active ingredient and a large amount of water cannot be ignored.
The present invention aims to provide an original alternative to the problems mentioned above in that the formulations proposed are powders containing high concentrations of active ingredient initially in the form of a hydrophobic liquid.
The invention thus provides water-redispersible granules comprising: derivatives; weak polyacid family.
The invention also provides a process for preparing such granules consisting of carrying out the following steps: one non ionic surfactant, and at least one hydrosoluble compound;
The granules of the present invention have the following advantages.
Firstly, their conformation can avoid all of the problems of using emulsions. Thus problems of instability on storage are avoided, such as creaming, flocculation, ageing and coalescence. These different phenomena have been described in the "ENCYCLOPEDIA OF EMULSIONS TECHNOLOGY", volume 1, by Paul BECHER published by MARCEL DEKKER INC., 1983.
A further advantage of the present invention is that the concentrations of active ingredients can be very high compared with emulsions. As a result, during use of these granules, a smaller quantity of granules will suffice.
Further, the conformation of the invention can overcome the problem of deactivation of the active ingredient when it is sensitive to hydrolysis.
The present invention can also provide a pre-formulation in the form of granules which are thus easier to use than emulsions, for example in the case where the pre-formulation is added to a powder formulation.
Further, the granules of the invention, prepared from an emulsion, have the advantage of redispersing spontaneously in water, to produce again an emulsion with a granulometry close to that of the initial emulsion.
Finally, the present invention provides a solution to the problems of liquid product conformations which are normally formulated by absorption on a support. The concentration of active ingredient in such formulations is often low and there may be phase separation between the support and the active ingredient by migration of the active ingredient during storage.
Further advantages and characteristics will become more clear from the following description and examples.
As indicated above, the granules of the invention comprise at least one active ingredient in the form of a hydrophobic liquid.
All active ingredients are suitable provided that at ambient temperature they are in the form of a liquid which is non miscible in or very slightly miscible with water or are dissolved in an organic solvent.
The term "slightly miscible" means active ingredients with a solubility in water not exceeding 10% by weight.
The term "active ingredient" means either pure active ingredient or active ingredient dissolved in a solvent, or a solvent.
Examples of active ingredients in the food industry are mono-, di- and tri-glycerides, essential oils, flavourings, and colorants.
Examples of active ingredients in the cosmetics industry are silicone oils, for example from the dimethicone family.
Examples of active ingredients suitable for implementing the invention in the paint industry are alkyl resins, epoxy resins, and block or n
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patent: 4490407 (1984-12-01), Lafon
patent: 4548734 (1985-10-01), Chaux et al.
patent: 4571422 (1986-02-01), Symes et al.
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Database WPI Derwent Publications, Ltd., London, GB; AN 81-50852d XP 002008139 & JP,A,56061 497 (Nippon Surfactant KK), May 26, 1981 "Pulverise Oil Substance Forming Medium Oil Type Emulsion Mix Polyhydric Alcohol Hydrophilic Sugar Fatty Acid Ester".
Database WPI Derwent Publications, Ltd., London, GB; AN 93-330525 XP 002008140 & JP,A,05 236,886 (Lion Corp), Sep. 17, 1993 "Powder Emulsion Composition Food Comprise Spray Dry Mixture Saturate Fatty Acid Mono Glyceride Obtain Heat Resistance Fix Lipase Succinic Acid Ester Saturate Fatty Acid Monoglyceride".
Bibette Jerome
Guerin Gilles
Morvan Mikel
Lovering Richard D.
Rhodia Chimie
Seugnet Jean-Louis
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