Water-insoluble penicillin acylase preparation

Details Water-insoluble penicillin acylase preparation Water-insoluble penicillin acylase preparation

1978-10-27

1980-10-28

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435181, 435231, C07G 702

Patent

active

042308046

ABSTRACT:
Novel re-usable water-insoluble penicillin acylase complexes are provided wherein a penicillin acylase is adsorbed on a water-insoluble polymer or co-polymer of methacrylic acid and cross-linked with a water-soluble aldehyde selected from the group consisting of glutaraldehyde, glyoxal and formaldehyde. The complexes are useful in the production of 6-APA from penicillins G and V.

REFERENCES:
patent: 3705084 (1972-12-01), Reynolds
patent: 3860490 (1975-01-01), Guttag
patent: 3871964 (1975-03-01), Huper et al.
patent: 3883394 (1975-05-01), Savidge et al.
patent: 3910825 (1975-10-01), Huper et al.
patent: 3983001 (1976-09-01), Coupek et al.

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