Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1987-09-18
1991-03-05
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
436534, 435 734, 435 36, 435 5, 422 56, 523201, 525902, G01N 33546
Patent
active
049977725
ABSTRACT:
A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg.sub.1) less than about 100.degree. C. The particle also has an outer shell comprising a second polymer for which the tracer material has substantially less affinity relative to said first polymer. This second polymer has a glass transition temperature (Tg.sub.2) which is greater than or equal to the term [Tg.sub.1 -10.degree. C] It also contains groups which are either reactive with free amino or sulfhydryl groups of an immunoreactive species or which can be activated for reaction with such groups. Such a species can be covalently attached to this particle to form an immunoreactive reagent which is useful in analytical elements and various analytical methods including immunological methods, for example, agglutination assays.
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Danielson Susan J.
Littlehale Susan B.
Sutton Richard C.
Eastman Kodak Company
Snay Jeffrey R.
Tucker J. Lanny
Warden Robert J.
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