Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-12-17
1995-03-28
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424604, 424639, 514836, 436173, 1286534, 128654, A61B 5055, A61K 3342, A61K 3332
Patent
active
054014921
ABSTRACT:
This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns.
In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate.
In another preferred embodiment, the composition of the present invention further comprises a surfactant.
The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.
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Gunther Wolfgang H. H.
Karpinski Piotr H.
Kellar Kenneth E.
Liversidge Elaine
McIntire Gregory L.
Davis William J.
Hollinden Gary E.
Sterling Winthrop Inc.
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