Water insoluble drugs coated by coacervated fish gelatin

Details Water insoluble drugs coated by coacervated fish gelatin Water insoluble drugs coated by coacervated fish gelatin

1988-06-15

1991-07-30

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424490, 424491, 424492, 514801, 514774, 530354, 530857, 426576, A61K 950, A61K 964

Patent

active

050358960

ABSTRACT:
According to this invention, the combination of a solid particulate water insoluble drug with a solid fish gelatin coating is produced by coacervation of the fish gelatin. The fish gelatin being soluble at ambient temperatures provides a basis for relatively low temperature coacervation impossible with other gelatins. Coacervation is brought about by the addition of conventional coacervation agents and the coacervating suspension containing gelatin and the agents is rendered insoluble by the addition of a suitable fixative such as glutaraldehyde.

REFERENCES:
patent: Re24899 (1960-11-01), Green
patent: 3876803 (1975-04-01), Stephan et al.
patent: 3984391 (1976-10-01), Nitschmann et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4273672 (1981-06-01), Vassiliades

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