Water-insoluble derivatives of hyaluronic acid and their methods

Details Water-insoluble derivatives of hyaluronic acid and their methods Water-insoluble derivatives of hyaluronic acid and their methods

1992-07-28

1994-10-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514777, 424 71, 424488, 536 41, A61K 31725, A61K 31735, A61K 4726, C08L 100

Patent

active

053568834

ABSTRACT:
This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

REFERENCES:
patent: 4582865 (1986-04-01), Balazs et al.
patent: 4713448 (1987-12-01), Balazs et al.
patent: 4937270 (1990-06-01), Hamilton et al.
patent: 4973493 (1990-11-01), Guire
patent: 5017229 (1991-05-01), Burns et al.
patent: 5128326 (1992-07-01), Balazs et al.
Kuo, Jing-wen, "Syntheses and Properties of Hyaluronic Acid Modified by Designed Carbodiimides," Dissertation Abstracts International, 50(12):5626 (1990).

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