Water-insoluble derivatives of hyaluronic acid and their methods

Details Water-insoluble derivatives of hyaluronic acid and their methods Water-insoluble derivatives of hyaluronic acid and their methods

1995-12-05

2000-01-11

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carbohydrate or lignin, or derivative

1061622, 2523153, 424447, 424449, 424488, 514 54, A61K 970, C08L 508, C09D10508, C09J10508

Patent

active

060136790

ABSTRACT:
This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

REFERENCES:
patent: 4582865 (1986-04-01), Balazs et al.
patent: 4713448 (1987-12-01), Balazs et al.
patent: 4937270 (1990-06-01), Hamilton et al.
patent: 4973493 (1990-11-01), Guire
patent: 5017229 (1991-05-01), Burns et al.
patent: 5128326 (1992-07-01), Balazs et al.
Kuo, Jing-wen, "Synthesis and Properties of Hyaluronic Acid Modified by Designed Carbodiimides," Dissertation Abstracts International, 50(12) :5626 (1990).

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