Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carbohydrate or lignin – or derivative
Patent
1987-09-18
1990-06-26
Bell, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Carbohydrate or lignin, or derivative
424 71, 424488, 536 41, 2523153, A61K 4726
Patent
active
049372700
ABSTRACT:
A method for making a water insouble bicompatible gel includes activating HA with an activating agent to form activated HA, and reacting the activated HA with a nucleophile, under conditions producing the water insoluble bicompatible gel. Also, a method for making a water insoluble biocompatible film includes providing a biocompatible gel made according to the above method, and drying the gel or compressing the gel under conditions permitting escape of water from the gel. Also, a water insoluble composition including HA is prepared without the use of any bifunctional or polyfunctional nucleophile.
REFERENCES:
patent: 4582865 (1986-04-01), Balazs et al.
patent: 4774093 (1988-09-01), Provonchee et al.
Sparer et al., "Controlled Release from Glycosaminoglycan Drug Complexes", Chapter 6, Controlled Release Delivery Systems.
I. Danishefsky et al., "Conversion of Carboxyl Groups of Mucopolysaccharides into Amides of Amino Acid Esters", Carbohydrate Research--An Internation Journal.
T. C. Laurent et al., "Cross-Linked Gels of Hyaluronic Acid", Acta Chemica Scandinavica, vol. 18, 1984, No. 1, (1-282).
Acharya Raksha A.
Fox Ellen M.
Hamilton Raymond
Walts Alan E.
Bell Mark L.
Brunsman David M.
Genzyme Corporation
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