Water-in-oil-in-polar solvent emulsions

Details Water-in-oil-in-polar solvent emulsions Water-in-oil-in-polar solvent emulsions

2000-06-14

2002-06-25

Pryor, Alton (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Wearing apparel, fabric, or cloth

C424S070120

Reexamination Certificate

active

06410038

ABSTRACT:

CROSS-REFERENCE TO RELATED APPLICATIONS
Not applicable.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not applicable.
REFERENCE TO A MICROFICHE APPENDIX
Not applicable.
FIELD OF THE INVENTION
This invention is directed to water-in-oil-in-polar solvent multiple emulsions W/O/PS in which the polar solvent (PS) is a non-aqueous polar solvent(s).
BACKGROUND OF THE INVENTION
Multiple emulsions containing silicone compositions are known in the art. For example, U.S. Pat. No. 5,948,855 (Sep. 7, 1999), assigned to the assignee of this invention, discloses certain water-in-oil-in-water (W
1
/O/W
2
) type multiple emulsions. In copending application U.S. Ser. No. 09/352,006, filed Jul. 12, 1999, assigned to the assignee of this invention, certain oil and water in oil three phase emulsions are described. In copending application U.S. Ser. No. 09/435,561, filed Nov. 8, 1999, and U.S. Ser. No. 09/498,714, filed Feb. 7, 2000, both assigned to the assignee of this invention, certain polar solvent-in-oil-in-water (PS
1
/O/W) type multiple emulsions, as well as certain polar solvent-in-oil-in-polar solvent (PS
1
/O/PS
2
) type multiple emulsions, are described.
However, none of the common assignee's prior references disclose a water-in-oil-in-polar solvent (W/O/PS) type multiple emulsion containing a silicone composition, which is the subject matter of the present invention. One advantage offered by a multiple emulsion of the type W/O/PS is that it can be used to isolate active ingredients which are soluble in similar phases from one another. This is particularly applicable when one active ingredient is very soluble in water W, but only marginally soluble in the non-aqueous polar solvent PS, while the other active ingredient is very soluble in PS and marginally soluble in W. Benefits can be most easily attained, however, when the active ingredients are basically insoluble in the oil O, in order to minimize their transport through O.
BRIEF SUMMARY OF THE INVENTION
The invention relates to a water-in-oil-in-non-aqueous polar solvent W/O/PS type multiple emulsion containing a water phase W dispersed in an oil O as the first continuous phase of primary emulsion W/O by an emulsifier. Primary emulsion W/O is dispersed in a second continuous non-aqueous polar solvent phase PS to form multiple emulsion W/O/PS.
The emulsifier is (i) a silicone elastomer containing polyether groups which is a network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon; (ii) a silicone elastomer containing acrylate/methacrylate grafted polyether groups which is a network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon; or (iii) a silicone elastomer containing polyether groups and alkyl groups with at least ten carbon atoms which is a network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon. In these emulsifiers, the silicone elastomer contains the continuous oil phase O, preferably a silicone oil, although it may contain other types of oils.
These and other features of the invention will become apparent from a consideration of the detailed description.
BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING
Not applicable.
DETAILED DESCRIPTION OF THE INVENTION
As noted above, emulsifier (i) for preparing multiple emulsions according to this invention is a silicone elastomer containing polyether groups which is a network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon. Methods for preparing this type of silicone elastomer are described in detail in the common assignee's U.S. Pat. No. 5,811,487 (Sep. 22, 1998), incorporated herein by reference.
Generally, such silicone elastomers are prepared by reacting (A) an ═Si—H containing polysiloxane; (B) a mono-alkenyl polyether; (C) an &agr;,&ohgr;-unsaturated hydrocarbon such as an &agr;,&ohgr;-diene, &agr;,&ohgr;-diyne, or an &agr;,&ohgr;-ene-yne, in the presence of (D) an oil and (E) a platinum catalyst, until a silicone elastomer is formed by crosslinking and addition of ═SiH across double or triple bonds in the &agr;,&ohgr;-unsaturated hydrocarbon (C).
Emulsifier (ii) for preparing multiple emulsions according to this invention is a silicone elastomer containing acrylate/methacrylate grafted polyether groups which is a network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon. Methods for preparing this type of silicone elastomer are described in detail in the common assignee's U.S. Pat. No. 5,969,035 (Oct. 19, 1999), incorporated herein by reference.
Generally, such silicone elastomers are prepared by reacting (A) an ═Si—H containing polysiloxane; (B) a monoacrylate or monomethacrylate functionalized polyether; (C) an &agr;,&ohgr;-unsaturated hydrocarbon such as an &agr;,&ohgr;-diene, &agr;,&ohgr;-diyne, or an &agr;,&ohgr;-ene-yne, in the presence of (D) an oil and (E) a platinum catalyst, until a silicone elastomer is formed by crosslinking and addition of ═SiH across double or triple bonds in the &agr;,&ohgr;-unsaturated hydrocarbon (C).
Emulsifier (iii) for preparing multiple emulsions according to this invention is a silicone elastomer containing polyether groups and alkyl groups with at least ten carbon atoms which is network of polymeric molecules crosslinked with an &agr;,&ohgr;-unsaturated hydrocarbon. Methods for preparing this type of silicone elastomer are described in detail in the common assignee's copending application U.S. Ser. No. 09/352,006, filed Jul. 12, 1999, referred to above, and incorporated herein by reference.
Generally, such silicone elastomers are prepared by combining and reacting (A) an ═Si—H containing polysiloxane; (B) a mono-alkenyl polyether; (C) an &agr;-olefin containing at least ten carbon atoms; (D) an &agr;,&ohgr;-unsaturated hydrocarbon such as an &agr;,&ohgr;-diene, &agr;,&ohgr;-diyne, or an &agr;,&ohgr;-ene-yne, in the presence of (E) an oil, and (F) a platinum catalyst, until a silicone elastomer is formed by crosslinking and addition of ═SiH across double or triple bonds in the &agr;,&ohgr;-unsaturated hydrocarbon (D).
The &agr;,&ohgr;-unsaturated hydrocarbon can be an &agr;,&ohgr;-diene of the formula CH
2
═CH(CH
2
)
d
CH═CH
2
where d is 1-20. Some representative examples of suitable &agr;,&ohgr;-dienes are 1,4-pentadiene; 1,5-hexadiene; 1,6-heptadiene; 1,7-octadiene; 1,8-nonadiene; 1,9-decadiene; 1,11-dodecadiene; 1,13-tetradecadiene; and 1,19-eicosadiene. Other &agr;,&ohgr;-unsaturated hydrocarbons which can be used include &agr;,&ohgr;-diynes of the formula CH≡C(CH
2
)
e
C≡CH; or &agr;,&ohgr;-ene-ynes of the formula CH
2
═CH(CH
2
)
e
C≡CH where e is 0-20. Some representative examples of suitable &agr;,&ohgr;-diynes are 1,3-butadiyne HC≡C—C≡CH and 1,5-hexadiyne (dipropargyl) HC≡C—CH
2
CH
2
—C≡CH. One example of a suitable &agr;,&ohgr;-ene-yne is hexene-5-yne-1 CH
2
═CHCH
2
CH
2
C≡CH.
The common assignee's U.S. Pat. Nos. 5,811,487 and 5,889,108 contain extensive lists of appropriate oils which can be used, among which are for example, (i) volatile polydimethylsiloxanes such as hexamethyldisiloxane, octamethyltrisiloxane, and decamethylcyclopentasiloxane, (ii) nonvolatile polydimethylsiloxanes having a viscosity generally in the range of 5-1,000 centistoke (mm
2
/s), (iii) fragrances such as musk and myrrh, and mixtures thereof.
Organic oils such as natural oils derived from animal, vegetable, or mineral sources are also suitable. Most preferred are modern cosmetic oils known to be safe for cosmetic purposes such as almond oil, apricot kernel oil, avocado oil, cacao butter (theobroma oil), carrot seed oil, castor oil, citrus seed oil, coconut oil, corn oil, cottonseed oil, cucumber oil, egg oil, jojoba oil, lanolin oil, linseed oil, mineral oil, mink oil, olive oil, palm kernel oil, peach kernel oil, peanut oil, rapeseed oil, safflower oil, sesame oil, shark liver oil, soybean oil, sunflower seed oil, sweet almond oil, tallow (beef) oil, tallo

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