Water-in-oil adjuvant composition

Details Water-in-oil adjuvant composition Water-in-oil adjuvant composition

1974-11-19

1976-09-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 424365, A61K 3902, A61K 3912, A61K 3918, A61K 4700

Patent

active

039832287

ABSTRACT:
Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.

REFERENCES:
patent: 3435112 (1969-03-01), Kuhns et al.
Salk - J.A.M.A. - vol. 151 No. 14 (1953) pp. 1169-1175.
Bollinger - J. of Pharmaceutical Sciences vol. 59 No. 8 (Aug. 1970) pp. 1088-1092.

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