Water-dispersible tablets

Details Water-dispersible tablets Water-dispersible tablets

1996-06-06

1997-12-16

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424465, A61K 934

Patent

active

056982267

ABSTRACT:
A water-dispersible tablet comprises an active compound such as acyclovir or lamotrigine and a dispersing agent. The dispersing agent is a swellable clay such as a smectite, e.g. Veegum F or bentonite, and is generally present within the granules of the tablet to provide a tablet which is capable of dispersing in water within 3 minutes to provide a dispersion which will pass through a 710 .mu.m sieve. The tablet can be optionally film-coated in which case the dispersion time is less than 5 minutes.

REFERENCES:
patent: 3427379 (1969-02-01), Barry et al.
patent: 3432593 (1969-03-01), Shepard
patent: 3567819 (1971-03-01), Leonia et al.
patent: 4072535 (1978-02-01), Short et al.
patent: 4086335 (1978-04-01), Bruscata et al.
patent: 4159345 (1979-06-01), Takeo et al.
patent: 4209513 (1980-06-01), Toroda
patent: 4251513 (1981-02-01), Moore et al.
patent: 4304773 (1981-12-01), Wong et al.
patent: 4305502 (1981-12-01), Gregory et al.
patent: 4322449 (1982-03-01), Voss et al.
patent: 4369308 (1983-01-01), Trubiano
patent: 4371516 (1983-02-01), Gregory et al.
patent: 4414198 (1983-11-01), Michaelson
patent: 4517179 (1985-05-01), Raghunathan
patent: 4600579 (1986-07-01), Salpekar et al.
patent: 4602017 (1986-07-01), Sawyer et al.
patent: 4631305 (1986-12-01), Guyer et al.
patent: 4661521 (1987-04-01), Salpekar et al.
patent: 4711777 (1987-12-01), Tan et al.
patent: 4757090 (1988-07-01), Salpekar et al.
patent: 4774083 (1988-09-01), Tan et al.
patent: 4781925 (1988-11-01), Michelucci et al.
patent: 4832956 (1989-05-01), Gergely et al.
patent: 4837031 (1989-06-01), Denton et al.
patent: 4847249 (1989-07-01), Sawyer et al.
patent: 4904477 (1990-02-01), Ho et al.
patent: 4910023 (1990-03-01), Botzolakis et al.
patent: 4925676 (1990-05-01), Selassie et al.
patent: 4927639 (1990-05-01), Selassi et al.
patent: 4950484 (1990-08-01), Olthoff et al.
patent: 4965072 (1990-10-01), Alexander et al.
patent: 4968517 (1990-11-01), Gergely et al.
patent: 4970078 (1990-11-01), Holinej
patent: 4999200 (1991-03-01), Casillan
patent: 5006345 (1991-04-01), Lang
patent: 5037658 (1991-08-01), Urban et al.
patent: 5047247 (1991-09-01), Milovac et al.
patent: 5049586 (1991-09-01), Ortega et al.
patent: 5064656 (1991-11-01), Gergely et al.
patent: 5069910 (1991-12-01), Kovacic et al.
patent: 5073377 (1991-12-01), Alexander et al.
patent: 5085869 (1992-02-01), Olthoff et al.
patent: 5087454 (1992-02-01), Duerholz et al.
patent: 5136080 (1992-08-01), Miller et al.
Veegum--The Supernatural Ingredient: R. T. Vanderbilt & Co., Booklet (1987).
Pharmasorb: Lawrence Industries, pp. 1-10 (1986).
Wai et al "Applications of the Montmorillonites in Tablet Making" J. Pharm. Sci., 55: 1244-1248 (1966).
Wai & Banker "Some Physicochemical Properties of the Montmorillonites" J. Pharm. Sci., 55, 1215-1220 (1966).
Mastery in Refinement-Magnabrite & Polargel: American Colloid Co.
Granberg et al "The use of Dried Bentonite as a Disintegrating Agent in Compressed Tablets of Thyroid" J. Am.Pharm.Assoc. Sci., 43: 648-7651 (1949).
Gross et al "A Comparative Study of Tablet disintegrating Agents."J. Am. Pharm. Assoc. Sci., 41: 157-161 (1952).
Firouzabadian et al "Some recently Developed Chemicals as Disintegrating Agents for Compressed Tablets": J. Am.Pharm.Assoc. Sci., 43 248-250 (1954).
Ward et al "Evaluation of Tablet Disintegrants" Drug Cosmetic Ind. 91:35-36, 92, 110-111 (1962).
Nair et al "Studies on Disintegration of Compressed Tablets I. Effect on Disintegration of the Procedure Used in Incorporating the Disintegrating Agent": J. Am Pharm.Assoc. Sci., 46: 131-134 (1957).
Patel et al "Veegum as Binding Agent for Compressed Tablets" Indian J. Pharm., 19: 4-10 (1957).
Feinstein et al "Comparative Study of Selected Disintegrating Agents": J. Pharm. Sci. 55: 332-334 (1966).
Varley, A. "The generic inequivalence of Drugs" JAMA, 206: 1745-1748 (1968).
Delonca et al "Study of the Activity of Some Disintegrants as a Function of Procedure and of the Solubility of the Active Principles" J. Pharm. Belg. 26(4): 447-458 (1971)-English translation.
Wagner et al "In vivo and In vitro availability of Commercial Warfarin Tablets" J. Pharm. Sci. 60: 666-677 (1971).
McGinty et al "Optimization of Slow-Release Tablet Formulations Containing Montmorillonite I. Properties of Tablets" Drug Development and Industrial Pharmacy 6: 399-410 (1980).
Bargava et al "An Evaluation of Smecta as a Tablet Disintegrant and Dissolution Aid" Drug Development and Industrial Pharmacy 17: 2093-2102 (1991).
Barr, M. "In Pharmaceutical Systems . . . Clays as Dispersion Stabilizers" J. Amer. Pharm. Assoc. Sci. Ed. 46: 486-493 (1957).
U.S.Pharmacopoeia, pp. 579, 1573, 1574, 1534 and 1535 (1985).
British Pharmacopoeia, pp. 27, 28, 51, 52, 62, 323-325 (1985).
Martindale, The Extra Pharmacopoeia, 29th Edition, 1077, 1092 and 1433.
The Handbook of Pharmaceutical Excipients, pp. 9-11, 150-152, 16-169.
Armstrong, N. "Tableting" from Pharmaceutics: The Science of Dosage Form Design (Ed. Aulton):647-668 (1988).
Rubinstein, M. "Tablets" from Pharmaceutics The Science of Dosage Form Dosage, (Ed. Aulton): 304-321 (1988).
Rudnic et al "Oral Solid Dosage Forms" from Remington's Pharmaceutical Sciences (Ed. Gennaro) pp. 1633-1665 (1990).
Disanto, A. "Bioavailability and Bioequivalency Testing" from Remington's Pharmaceutical Sciences (ed. Gennaro), pp. 1451-1458 (1990).
Banker et al "Tablets" from The Theory and Practice of Industrial Pharmacy, pp. 293-345.
Marshall et al "Tablet Dosage Forms" from Modern Pharmaceutics (ed. Banker G & Rhodes C) pp. 355-425 (1990).
Shangraw R. "Specialty Tablet and Capsules" from Modern Pharmaceutics (eds. Banker, G & Rhodes, C) pp. 427-440 (1990).

Affiliated with

Also associated with

Rating

Water-dispersible tablets does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Water-dispersible tablets, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water-dispersible tablets will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-203169