Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
C07F 1500, A61K 3128
Platinum complexes are disclosed in which the formula is ##STR1## wherein A and B are each independently ammine or monodentate amine, or A and B taken together represent a bidentate amine, and A and B are coordinated to the platinum atom through their nitrogen atom; X and Y are each independently halogen; R' is C.sub.1 -C.sub.20 alkanoyl, aroyl, heteroaroyl, or a group selected from the group consisting of ##STR2## wherein u' is an integer from 1 to 5; and R" is hydrogen with the proviso that A, B, X, and Y are structually equatorial substituents with respect to OR'--Pt--OR". These platinum complexes show antitumor activity with relatively lower kidney or bone marrow toxicity.
patent: 4119653 (1978-10-01), Tobe et al.
patent: 4119654 (1978-10-01), Tobe et al.
patent: 4431666 (1984-02-01), Bulten et al.
patent: 4466924 (1984-08-01), Verbeek et al.
patent: 4581224 (1986-04-01), Borch
patent: 4594238 (1986-06-01), Borch
patent: 4658047 (1987-04-01), Vishnuvajjala
patent: 4921984 (1990-05-01), Nowatari et al.
patent: 5028727 (1991-07-01), Verbeek et al.
patent: 5034553 (1991-07-01), Verbeek et al.
Bondarenko, V. S., et al., Zh. Neorg. Khim., 1982, 27 (5):1234-1238 (Chem. Abst. 97:48589d) [Abstract Only].
Cowens, J. W., et al., Int. J. Mass. Spectrom. Ion Phys., 1983, (48):177-180 (Chem. Abst. 98:118519c) [Abstract Only ].
Al-Ansari, S. V., Chem. Abst., 1984, 101:182625s [Abstract Only].
Bogardus Joseph B.
Kaplan Murray A.
Perrone Robert K.
Wilcox Kenneth J.
Bristol--Myers Squibb Company
Prescott Arthur C.
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