Wasp family protein fragments, and use thereof

Details Wasp family protein fragments, and use thereof Wasp family protein fragments, and use thereof

2006-06-20

2006-06-20

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C514S012200, C530S300000, C435S402000

Reexamination Certificate

active

07063829

ABSTRACT:
The invention concerns peptide fragments of the WASP family proteins, or peptides derived from said fragments, and their uses in particular for preparing reagents for use in implementing a method for detecting or screening molecules with inhibiting or stimulating effect on the formation of the actin cytoskeleton, hence an inhibiting or stimulating effect on cellular motility.

REFERENCES:
Higgs, H. et al. “Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASP) and the Arp2/3 Complex on Actin Polymerization.” Biochemistry 38: 15212-15222 1999.
Symons et al. Cell 84: 723-734 (1996).
Kato et al. Journal of Biological Chemistry 274(38): 27225-27230 (1999).
Miki, H. and Takenawa, T. J. Biochem 134: 309-313 (2003).
Higgs et al. “Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization”, BIOCHEMISTRY, vol. 38, No. 46, Nov. 16, 1999, pp. 15212-15222.
Linder et al. “Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages”, Proceedings of the National Acadamey of Sciences of USA, vol. 96, No. 17, Aug. 17, 1999, pp. 9648-9653.
Linder et al. “The Polarization Defect of Wiskott-Aldrich Syndrome Macrophages Is Linked to Dislocalization of the Arp2/3 Complex”, Journal of Immunology, vol. 165, No. 1, Jul. 1, 2000, pp. 221-225.
Yarar et al. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex, Current Biology, vol. 9, No. 10, May 20, 1999, pp. 555-558.

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