Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Aldehyde doai
Reexamination Certificate
2001-12-10
2004-01-06
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Aldehyde doai
C514S693000, C514S729000, C514S730000, C424S439000, C424S401000
Reexamination Certificate
active
06673844
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to a warming composition which produces an excellent warming effect of long duration with no or little skin irritation, a fragrant composition comprising the warming composition, and cosmetics, toiletries, bath additives, and pharmaceuticals containing the warming composition or the fragrance composition.
BACKGROUND OF THE INVENTION
Substances which are known to provide a sensation of warmth on application and called “warming agents” include polyhydric alcohols, capsicum (red pepper) powder, a capsicum tincture, capsicum extract, capsaicin, homocapsaicin, homodihydrocapsaicin, nonanoyl vanillyl amide, nonanoic acid vanillyl ether, vanillyl alcohol alkyl ether derivatives (JP-A-57-9729), such as vanillyl ethyl ether, vanillyl butyl ether, vanillyl pentyl ether, and vanillyl hexyl ether, isovanillyl alcohol alkyl ethers, ethylvanillyl alcohol alkyl ethers, veratryl alcohol derivatives, substituted benzyl alcohol derivatives, substituted benzyl alcohol alkyl ethers, vanillin propylene glycol acetal, ethylvanillin propylene glycol acetal, ginger extract, ginger oil, gingeol, and gingeron.
These warming agents are added either as such or in the form of a fragrance composition to various products to produce a warming effect. However, the known warming agents often cause strong skin irritation or exhibit insufficient warming effects, and those having high warming effects are of short duration or, when used in a reduced amount, have insufficient warming effects or an insufficient duration of effect.
An object of the present invention is to provide a warming composition which is freed of these problems, i.e., causes no or little skin irritation and exhibits an excellent and long-lasting warming effect in a small amount.
Another object of the present invention is to provide a fragrance composition which causes no or little skin irritation and imparts a long-lasting warming effect when added in a small amount.
Still another object of the invention is to provide cosmetics, toiletries, bath additives and pharmaceuticals which contain the warming composition or the fragrance composition and exhibit excellent and long-lasting warming effects.
SUMMARY OF THE INVENTION
As a result of extensive investigations, the inventors have found that a combination of (A) a compound or a composition that has been known as a cooling agent (hereinafter inclusively referred to as a cooling agent) and a small amount of a compound represented by formula (I) (B) and/or (C) a compound or a composition that has been known as a warming agent (hereinafter inclusively referred to as a warming agent) produces such a warming effect as is never expected from each of the components used alone and as lasts as long as 3 hours or even more, and, when added to a product, exhibits an appreciable warming effect in such a low concentration at which each component would not stimulate individually, making it possible to produce a warming effect with no skin irritation that has not heretofore been attained.
The present invention provides a warming composition comprising (A) a cooling agent and (B) a compound represented by formula (I):
wherein R
1
represents a hydrogen atom, a methyl group or an ethyl group.
The present invention provides a warming composition comprising (A) a cooling agent and (C) a warming agent.
The present invention provides a warming composition comprising (A) a cooling agent, (B) a compound represented by formula (I), and (C) a warming agent.
The present invention also provides a fragrance composition comprising any of the above-described warming compositions.
The present invention also provides cosmetics, toiletries, bath additives or pharmaceuticals comprising any of the above-described warming compositions or the above-described fragrance composition.
In the present invention, a combination of a cooling agent and at least one of a warming agent and a specific compound produces an appreciable warming effect at such a low concentration at which each component alone is ineffective. The warming effect of the warming composition lasts for a long period of time that has not been thought. The warming composition is unlike conventional ones in that when it is applied to one's sole, the warming effect is also produced in her or his back, etc.
DETAILED DESCRIPTION OF THE INVENTION
The warming composition of the present invention comprises (A) a cooling agent and at least one of (B) a compound represented by formula (I) and (C) a warming agent.
The cooling agent as component (A) can be any compound or composition known as a cooling agent. Typical examples of the cooling agents which can be used in the present invention include:
(1) a compound represented by formula (II):
wherein R
2
and R
3
each represent a hydrogen atom or a hydroxyl group (
represents a single bond or a double bond, the same definition applies hereinafter),
(2) a compound represented by formula (III):
wherein R
4
represents a hydrogen atom or a methyl group; R
5
represents a hydrogen atom, a lower alkyl group or a 2-alkoxyethyl group,
(3) a compound represented by formula (IV):
wherein n represents an integer of 1 to 10,
(4) a compound represented by formula (V):
wherein R
6
represents a hydrogen atom, a straight-chain or branched alkyl or alkenyl group, or a straight-chain or branched hydroxyalkyl group,
(5) l-menthylacetic acid N-ethylamide, and (6) N,2,3-trimethyl-2-(1-methylethyl)-butanamide.
Specific examples of the cooling agents which are preferably used in the invention include, but are not limited to, menthol, isopulegol, 3-(l-menthoxy)propane-1,2-diol, 3-(l-menthoxy)-2-methylpropane-1,2-diol, p-menthane-2,3-diol, p-menthane-3,8-diol, 6-isopropyl-9-methyl-1,4-dioxaspiro[4,5]decane-2-methanol, menthyl succinate and its alkaline earth metal salts, trimethylcyclohexanol, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Japanese mint (
Mentha arvensis
) oil, peppermint oil, menthone, menthone glycerol ketal, menthyl lactate, 3-(l-menthoxy)ethan-1-ol, 3-(l-menthoxy)propan-1-ol, 3-(l-menthoxy)butan-1-ol, l-menthylacetic acid N-ethylamide, l-menthyl-4-hydroxypentanoate, l-menthyl-3-hydroxybutyrate, N,2,3-trimethyl-2-(1-methylethyl)-butanamide, and spearmint oil.
Of these cooling agents preferred are 3-(l-menthoxy)propane-1,2-diol, 3-(l-menthoxy)-2-methylpropane-1,2-diol, p-menthane-3,8-diol, 3-(l-menthoxy)ethan-1-ol, 3-(l-menthoxy)propan-1-ol, and 3-(l-menthoxy)butan-1-ol. Still preferred are 3-(l-menthoxy)propane-1,2-diol and 3-(l-menthoxy)-2-methylpropane-1,2-diol.
Of the compounds represented by formula (I) as component (B) the compound in which R
1
is a methyl group, i.e., vanillin is preferred.
The warming agent as component (C) includes, but is not limited to,
(i) vanillyl alcohol, vanillyl alkyl or alkenyl ethers represented by formula (VI):
wherein R
7
represents a hydrogen atom or a straight chain or branched alkyl or alkenyl group having 1 to 10 carbon atoms, preferably 1 to 6 carbon atoms,
such as vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, vanillyl pentyl ether, and vanillyl hexyl ether;
(ii) vanillin propylene glycol acetal;
(iii) ethylvanillin propylene glycol acetal;
(iv) compounds represented by formula (VII):
wherein R
8
represents a straight-chain or branched alkyl or alkenyl group,
such as capsaicin and nonanoic acid vanillylamide;
(v) gingeron, capsicum tincture, and ginger extract.
Other substances that have been described as a warming agent in the background of the present invention can be used.
Of the above recited warming agents preferred are vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, vanillyl pentyl ether, vanillyl hexyl ether, gingeron, capsicum tincture, and ginger extract. Still preferred are vanillyl butyl ether, vanillyl pentyl ether, vanillyl hexyl ether, and capsicum tincture. Vanillyl butyl ether is the most preferred.
Component (B) is usually used in an amount of 0.000001 to 100 parts, preferably 0.0001 to 10 parts, still preferably 0.001 to 1 part, by weight per part by weight of compo
Kumamoto Hiroyasu
Ohta Hideaki
Kim Jennifer
Padmanabhan Sreeni
Takasago International Corporation
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