Waffle-like matrix for immunoassay and preparation thereof

Details Waffle-like matrix for immunoassay and preparation thereof Waffle-like matrix for immunoassay and preparation thereof

1980-03-02

1982-03-02

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

23230B, 260112R, 422 50, 422 57, 422 58, 422 61, 422 68, 435180, 435181, 424 1, 424 15, 424 13, 424 78, 525 541, G01N 3106, G01N 3348, G01N 3352, G01N 3354

Patent

active

043178103

ABSTRACT:
A disc-shaped insoluble matrix is formed of a polymeric material having a layer of reactive groups which react with proteins binding them covalently and uniformly to its surface. An antibody adapted for use in immunoassay of antigens associated with hepatitis is covalently bonded to the reactive groups. The matrix is provided with irregular, e.g., waffle-like, surfaces designed to increase the amount of antibody that will be in contact with a test solution such as serum.

REFERENCES:
patent: 3507618 (1970-04-01), Murty
patent: 3700609 (1972-10-01), Tregear
patent: 3853987 (1974-12-01), Dreyer
patent: 4157280 (1979-06-01), Halbert
Grabow, The J. of Infect. Dis., vol. 127, Feb. 1973, pp. 183-186.
Protapol DI/1, Imperial Chem. Ind., Melbourne, Australia, package flyer, 2 pp.
Bikarman, Physical Surfaces, Acd. Press, N.Y., Physical Chem. Monograph Series, vol. 20, 1970, pp. 169-193, 208-213.
British Catalogue of Plastics, The Nat. Trade Press, London, 1948, p. 109.

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