VPR mutant protein and its encoding gene having...

Details VPR mutant protein and its encoding gene having... VPR mutant protein and its encoding gene having...

2006-10-24

2006-10-24

Stucker, Jeffrey (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C536S023720, C530S826000, C514S002600, C514S04400A

Reexamination Certificate

active

07125957

ABSTRACT:
An apoptosis inducing agent which comprises a protein as being Vpr protein encoded by vpr gene of HIV-1 wherein 15 amino acid residues from the C-terminal are deleted, and an apoptosis inducing gene encoding said protein. The agent induces apoptosis of cells and therefore useful as a medicament for treatment of a cancer or AIDS.

REFERENCES:
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Nishizawa et al., “Apoptosis Induction by a Deficient Mutant of HIV-1 VPR Gene”, Program and Abstract of the 46thGeneral Meeting of the Japanese Society for Virology, Oct. 12-14, 1998 With partial English language translation of the same.

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