Von Willebrand Factor (Vwf)-cleaving protease

Details Von Willebrand Factor (Vwf)-cleaving protease Von Willebrand Factor (Vwf)-cleaving protease

2006-09-26

2006-09-26

Weber, Jon (Department: 1653)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S325000

Reexamination Certificate

active

07112666

ABSTRACT:
This invention is intended to isolate and identify a vWF-specific cleaving protease.The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val, and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.

REFERENCES:
patent: 2001/0049106 (2001-12-01), Buckbinder et al.
patent: 1 152 055 (2001-07-01), None
patent: WO 97/41206 (2000-07-01), None
patent: WO 02/26999 (2002-04-01), None
patent: WO 02 42441 (2002-05-01), None
Nozaki et al., NCBI Sequence Submission Accession No. AB069698.
Miha Furlan, et al., “Acquired Deficiency of von Willebrand Factor-Cleaving Protease in a Patient With Thrombotic Thtombocytopenic Purpura”, Blood, vol. 29, No. 8, pp. 2839-2846 (Apr. 15, 1998).
International Search Report.
Miha Furlan et al., “Partial Purification and Characterization of a Protease From Human Plasma Cleaving von Willebrand Factor to Fragments Produced by In Vivo Proteolysis”, Blood, vol. 87, No. 10, May 15, 1996, pp. 4223-4234.
Han-Mou Tsai, “Physiologic Cleavage of von Willebrand Factor by a Plasma Protease Is Dependent on Its Conformation and Requires Calcium Ion”, Blood, vol. 87, No. 10, May 15, 1996, pp. 4235-4244.
Kazuo Fujikawa et al., “Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family”, Blood, vol. 98, No. 6, Sep. 15, 2001, pp. 1662-1666.
Helena E. Gerritsen et al., “Partial amino acid sequence of purified von Willebrand factor-cleaving protease”, Blood, vol. 98, No. 6, Sep. 15, 2001, pp. 1654-1661.
Xinglong Zheng et al., “Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura”, The Journal of Biological Chemistry, vol. 276, No. 44, Nov. 2, 2001, pp. 41059-41063.
Kenji Soejima et al., “A Novel Human Metalloprotease Synthesized in the Liver and Secreted into the Blood: Possibly, the von Willebrand Factor-Cleaving Protease?”, J. Biochem. vol. 130, No. 4, 2001, pp. 475-480.
Gailla G. Levy et al., “Mutations in a member of theADAMTSgene family cause thrombotic thrombocytopenic purpura”, Nature, vol. 413, Oct. 4, 2001, pp. 488-494.

Affiliated with

Also associated with

Rating

Von Willebrand Factor (Vwf)-cleaving protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Von Willebrand Factor (Vwf)-cleaving protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Von Willebrand Factor (Vwf)-cleaving protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3602232