Voltage-dependent calcium channel beta subunit functional core

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C436S004000

Reexamination Certificate

active

07491523

ABSTRACT:
The present invention relates to crystallized forms of a voltage dependent calcium channel β subunit functional core, methods of producing and methods of utilizing the same.

REFERENCES:
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Opatowsky et al. The Voltage-Dependent Calcium Channel Beta Subunit Contains Two Stable Interacting Domains. The Journal of Biological Chemistry. vol. 278, No. 52, pp. 52323-52332.
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Chen, Y.H., Li, M H , Zhang, Y., He, L L , Yamada, Y., Fitzmaurice, A., Shen, Y., Zhang, H., Tong, L., and Yang, J. (2004). Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature 429, 675-680.
De Waard, M., Scott, V E., Pragnell, M , and Campbell, K. P. (1996). Identification of critical amino acids involved in alpha1-beta interaction in voltage-dependent Ca2+ channels FEBS Letters 380, 272-276.
Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, D.L. Jr (2004) Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 429, 671-675.
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