Vivo P-31 NMR imaging of phosphorus metabolites

Details Vivo P-31 NMR imaging of phosphorus metabolites Vivo P-31 NMR imaging of phosphorus metabolites

1983-06-09

1986-01-28

Karlsen, Ernest F.

Electricity: measuring and testing

Particle precession resonance

Using a nuclear resonance spectrometer system

324318, G01R 3322, G01N 2406

Patent

active

045674400

ABSTRACT:
A system for imaging P-31 spectra from different slices through a living body specimen positioned in the bore of the hollow main field magnet of an NMR spectrometer, consisting of applying a timed series of different discrete different-amplitude magnetic field gradient pulses to the specimen, whereby to generate time-spaced echo signals from respective points along the specimen while timed RF resonance excitation pulses are applied to the specimen. The echo signals are used to derive respective chemical shift spectra from the points, each spectrum containing information showing the in vivo metabolic state at one of the points. The various spectra can be simultaneously displayed to enable concurrent slice-by-slice interpretation of the metabolic information. The gradient pulses are derived from coils mounted inside the main field magnet arranged to generate a magnetic field vector traversing the specimen. The gradient coils are energized by using a suitably programmed computer. The gradient current pulses are applied concurrently with the RF excitation pulses.

REFERENCES:
patent: 4318043 (1982-03-01), Crooks et al.
patent: 4468621 (1984-08-01), Hinshaw
patent: 4490675 (1984-12-01), Knuettel et al.

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