Vivo enhancement of NMR relaxivity

Details Vivo enhancement of NMR relaxivity Vivo enhancement of NMR relaxivity

1986-05-07

1989-11-14

Rosenbaum, C. Fred

Surgery

Truss

Pad

424 9, A61K 4900

Patent

active

048800082

ABSTRACT:
A method of decreasing the NMR relaxation times (T.sub.1 or T.sub.2) of water protons in contact with a biological tissue, the method involving administering to a human patient an NMR contrast agent comprising a paramagnetic ion complexed with a chelating substance, the contrast agent being characterized in that it is capable of binding non-covalently and non-immunologically to a component of the tissue, and as a result of such binding is capable of enhancing relaxivity of the water protons by a factor of at least 2, compared to the relaxivity induced by the paramagnetic substance alone free in solution, and subjecting the patient to NMR imaging.

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Weinmann et al., "Characteristics of Gadolinium-DTPA Complex: a Potential NMR Contrast Agent", in AJR, Mar. 1984, pp. 619-624.
Chen et al., "Paramagnetic Metalloporphyrins as Potential Contrast Agents in NMR Imaging", in FEBS Letters, vol. 168, No. 1, Mar. 1984, pp. 70-74.

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