Vitronectin receptor antagonists, their preparation and their us

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142242, 5142305, 514258, 514261, 514266, 514301, 514302, 514303, 514367, 514375, 514379, 514309, 514381, 514382, 514383, 514405, 514414, 514416, 514418, 514443, 514469, 544 47, 544 48, 544 50, 544 90, 544 91, 544256, 544276, 544278, 544280, 544284, 544286, 546114, 546115, 546118, 546141, 548152, 548153, 548161, 548180, 548218, 548233, 548241, 548251, 548277, 5483027, 5483031, 5483037, 5483051, 5483071, 5483615, 5483626, 5483648, 548465, 548467, 548472, 549486, 549487, 549 55, 549467, A61K 31415, C07D40512

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active

059901454

ABSTRACT:
The present invention relates to compounds of the formula I,

REFERENCES:
Horton et al., "Arg-Gly-Asp (RGD) Peptides and the Anti-Vitronectin Receptor Antibody 23C6 Inhibit Dentine Resorption and Cell Spreading by Osteoclasts.sup.1 " Experimental Cell Research 195 pp. 368-375 (1991).
Sato et al., "Echistatin Is a Potent Inhibitor of Bone Resorption in Culture" The Journal of Cell Biology 111:1713-1723 (1990).
Fisher et al., "Inhibition of Osteoclastic Bone Resorption in Vivo by Echistatin, An "Arginyl-Glycyl-Aspartyl" (RGD)-Containing Protein" Endocrinology 132:1411-1413 (1993).
Brown et al., "Stimulation of migration of human aortic smooth muscle, cell by vitronectin: implications for atherosclerosis" Cardiovascular Research 28:1815-1820 (1994).
Brooks et al., "Integrin .alpha..sub..nu. .beta..sub.3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Bloos Vessels" Cell 79:1157-1164 (1994).
Friedlander et al., "Definition of Two Angiogenic Pathways by Distinct .alpha..sub..nu. Integrins" Science 270:1500-1502 (1995).
Engleman et al., A Peptidomimetic Antagonist of the .alpha..sub..nu. .beta..sub.3 Integrin Inhibits Bone Resorption In Vitro and Prevents Osteoporosis In Vivo J. Clin. Invest. 99:2284-2292 (1997).

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